Esomeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Ranbaxy (UK) Limited a Sun Pharmaceutical Company. Taking a proton pump inhibitor like Esomeprazole, especially over a period of more than one year, may slightly increase your risk of fracture in the hip, wrist or spine. Esomeprazole is acid labile and is administered orally as gastro-resistant granules. Medicines that are used to thin your blood, such as warfarin. This medicine can affect the results of certain medical tests. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. This includes any possible side effects not listed in this leaflet. When clopidogrel was given together with a fixed dose combination of esomeprazole 20 mg + ASA 81 mg compared to clopidogrel alone in a study in healthy subjects there was a decreased exposure by almost 40% of the active metabolite of clopidogrel. Symptoms can include: neuritis (inflammation of a nerve). Also tell your doctor if you still have symptoms of increased stomach acid even though youre taking this drug. An interaction is observed between clopidogrel and esomeprazole (see section 4.5). However, caution should be exercised when esomeprazole is given at high doses in elderly patients. If your doctor has found that your food pipe (gullet) has been slightly damaged, the recommended dose is one Esomeprazole 40 mg gastro-resistant tablet once a day for 4 weeks. These conditions include gastroesophageal reflux disease (GERD), erosive esophagitis, Zollinger-Ellison syndrome, and, regurgitation (burping up food) in babies, Bone breaks. Lactose monohydrate and cellulose microcrystalline, Additionally 40 mg gastro-resistant tablet contain. Esomeprazole is GREY restricted after the use of formulary PPIs. You may need to read it again. Use esomeprazole for the full prescribed length of time, even if your symptoms quickly improve. Strength: 20mg 40mg Pack Size: 28 Tablets 56 Tablets 84 Tablets 18.99 Start Consultation Order within 4d 12h 38m 35s to receive your order by Mon 9 Jan Generally feeling unwell and lacking energy. Esomeprazole is used to treat symptoms of gastroesophageal reflux disease ( GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Animal studies with the racemic mixture do not indicate direct or indirect harmful effects with respect to pregnancy, parturition or postnatal development. Cutaneous lupus erythematosus (CLE). This can cause weakness, bruising or make infections more likely. When flying, never put it into a checked bag. What Are the Differences Between Heartburn, Acid Reflux, and GERD? Esomeprazole, as all acid-blocking medicines, may reduce the absorption of vitamin B12 (cyanocobalamin) due to hypo- or achlorhydria. Then drink the mixture straight away or within 30 minutes. These changes are a physiological consequence of pronounced inhibition of acid secretion, are benign and appear to be reversible. HIV/AIDS medication--atazanavir, nelfinavir, saquinavir. Therefore, you should not take Esomeprazole if you are breast-feeding. Do not take these drugs with esomeprazole. Medicinal products which induce CYP2C19 and/or CYP3A4. OPA-AI-PE-dessicant-HDPE/AI blister with 7, 14, 15, 28, 30, 56, 60, 90 and 100 tablets, Polyamide-Al-PVC/Al cold form laminate blister 7, 14, 15, 28, 30, 56, 60, 90 and 100 tablets. When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents. For patients expected to be on prolonged treatment or who take PPIs with digoxin or medicinal products that may cause hypomagnesaemia (e.g., diuretics), health care professionals should consider measuring magnesium levels before starting PPI treatment and periodically during treatment. In two studies with ranitidine as an active comparator, esomeprazole showed better effect in healing of gastric ulcers in patients using NSAIDs, including COX-2 selective NSAIDs. 40 mg esomeprazole once daily for 4 weeks. Methotrexate (a chemotherapy medicine used in high doses to treat cancer) if you are taking a high dose of methotrexate, your doctor may temporarily stop your Esomeprazole treatment. For atazanavir and nelfinavir, decreased serum levels have been reported when given together with omeprazole and concomitant administration is not recommended. Esomeprazole magnesium is available as the brand-name drug Nexium and as a generic drug. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. If you are taking a medicine containing nelfinavir (used to treat HIV infection). A PPI and clopidogrel given concurrently may interact, resulting in reduced effectiveness of the . Brand: . During treatment with antisecretory medicinal products serum gastrin increases in response to the decreased acid secretion. Omeprazole as well as esomeprazole act as inhibitors of CYP2C19. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Patients on long-term treatment (particularly those treated for more than a year) should be kept under regular surveillance. Esomeprazole 40 mg gastro-resistant tablets: Pink coloured, capsule shaped, biconvex film coated tablets debossed '40' on one side and plain on other side. Theyre all esomeprazole, but they contain different salt forms. This can further decrease your low magnesium levels. 7. This belongs to a group of medicines called 'proton pump inhibitors'. Learn ways to prevent and relieve heartburn, like home remedies, medications, and changing, Heartburn is a burning sensation in your chest that often causes a bitter taste in your throat or mouth. Always carry your medication with you. fever, angioedema and anaphylactic reaction/shock. Always carry the original prescription-labeled container with you. The absolute bioavailability is 64% after a single dose of 40 mg and increases to 89% after repeated once daily administration. If your doctor has found that your food pipe (gullet) has been slightly damaged, the recommended dose is one Esomeprazole 40 mg tablet once a day for 4 weeks. Talk to your doctor if you breastfeed your child. These measures will help protect the environment. The apparent volume of distribution at steady state in healthy subjects is approximately 0.22 l/kg body weight. The text only version may be available in large print, Braille or audio CD. After repeated once daily administration of 40 mg esomeprazole, the mean area under the plasma concentration-time curve was approximately 100% higher in poor metabolisers than in subjects having a functional CYP2C19 enzyme (extensive metabolisers). These conditions include the following: This drug is also used to prevent stomach ulcers due to the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Eyesight problems such as blurred vision. Do not pass it on to others. Low blood levels of magnesium. Adverse reactions such as dizziness (uncommon) and blurred vision (rare) has been reported (see section 4.8). Esomeprazole is a CYP2C19 inhibitor. Take each dose with a full glass (8 ounces) of water. Available from: Liver problems, including jaundice which can cause yellow skin, dark urine, and tiredness. Healing of gastric ulcers associated with NSAID therapy. - Esomeprazole may cause serious side effects. Co-administration of omeprazole (40 mg once daily) with atazanavir 300 mg/ritonavir 100 mg to healthy volunteers resulted in a substantial reduction in atazanavir exposure (approximately 75% decrease in AUC, Cmax and Cmin). These findings have no implications for the posology of esomeprazole. symptoms can include: numbness and tingling in your hands and feet, menstrual bleeding thats heavier than normal, angioedema (swelling of your face, throat, or tongue), paleness or reddening of your face and body, panic attack or feeling of impending doom. Patients on on-demand treatment should be instructed to contact their physician if their symptoms change in character. You may need to show airport staff the pharmacy label for your medication. When suggestions are available use up and down arrows to review and ENTER to select. Serious cutaneous adverse reactions (SCARs). Esomeprazole magnesium oral capsule is used to treat conditions caused by too much acid production in your stomach. Also get Esomeprazole Tablet price list from verified companies | ID: 2849119126573 (This article is about esomeprazole magnesium.) This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially 'sodium-free'. Inconsistent data on the clinical implications of a PK/PD interaction of esomeprazole in terms of major cardiovascular events have been reported from both observational and clinical studies. If you use esomeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Find ways to relieve or prevent heartburn after eating. However, side effects such as dizziness and blurred vision may uncommonly or rarely occur (see section 4). However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. One week treatment with esomeprazole 20 mg b.i.d. This is where acid from the stomach escapes into the gullet (the tube which connects your throat to your stomach) causing pain, inflammation and heartburn. nonsteroidal anti-inflammatory drugs (NSAIDs), Esomeprazole may interact with other medications, Important considerations for taking esomeprazole, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f4ae091d-9b74-4a0e-ac68-057effd91e17, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f4853677-1622-4037-688b-fdf533a11d96. Do not use two doses at one time. To avoid this interference, esomeprazole treatment should be stopped for at least 5 days before CgA measurements (see section 5.1). The product code(s) for this leaflet is: PL 14894/0631. On the market today, there is a lot of information about Espoan products, but it is still incomplete. Esomeprazole is metabolised by CYP2C19 and CYP3A4. Remember to also mention any other ill-effects like pain in your joints. How to take Esomeprazole It can then be given to you through a tube directly into your stomach (gastric tube). General disorders and administration site conditions, Reporting suspected adverse reactions after authorisation of the medicinal product is important. Esomeprazole is extensively plasma protein bound and is therefore not readily dialyzable. Ulcers in the stomach or upper part of the gut (intestine) that are infected with bacteria called . Systemic lupus erythematosus (SLE). Uncommon (may affect up to 1 in 100 people), Rare (may affect up to 1 in 1,000 people), Very rare (may affect up to 1 in 10,000 people), Not known (frequency cannot be estimated from the available data). Do not chew or crush the tablets. Each tablet contains sucrose 87.4 mg and lactose (as lactose monohydrate 100.125 mg). Tablet core: Hydroxypropyl cellulose (E463), Crospovidone (Type A), Tablet coating: Povidone (K30), Macrogol-400, Macrogol-4000, Macrogol 6000, Hypromellose phthalate (HP-55S), Hypromellose phthalate (HP-50), Diethylphthalate, Hydroxypropyl cellulose, Microcrystaline cellulose (PH 101), Microcrystaline cellulose (PH 112), Crosspovidone (TypeB), Sodium stearyl fumarate, Opadry 03B86651 Brown (HMPC 2910/Hypromellose 6cP, Titanium Dioxide(E171), Macrogol/PEG 400, Iron Oxide red (E172)), Sugar spheres (sucrose and maize starch), Talc (E553b), Esomeprazole 20 mg gastro-resistant tablets are light brick red to brown coloured, oval, biconvex, film-coated tablets with E5 debossed on one side and plain on other side, Esomeprazole 40 mg gastro-resistant tablets are light brick red to brown coloured, oval, biconvex, film-coated tablets with E6 debossed on one side and plain on other side, Product is available in following pack sizes. 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